Press reportsww



63. M. Kim, Z. Zhang, H. Okano, D. Yan, A. Groisman, and T. Hwa, "Need-based activation of ammonium uptake in Escherichia coli", Molecular Systems Biology 8, 616 (2012) PDF

62. B.S. Razooky, E. Gutierrez, V.H. Terry, C.A. Spina, A. Groisman and L.S. Weinberger, "Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes", Lab on a Chip 12, 4305–4312 (2012) PDF

61. M. Adler, M. Erickstad, E. Gutierrez, and A. Groisman, "Studies of bacterial aerotaxis in a microfluidic device", Lab on a Chip 12, 4835-4847 (2012) PDF

60. W.F. Loomis, D. Fuller, E. Gutierrez, A. Groisman, and W.-J. Rappel "Innate Non-Specific Cell Substratum Adhesion", PLoS One 7, e42033 (2012) PDF

59.P. Sundd, E. Gutierrez, E. Koltsova, Y. Kuwano, S. Fukudo, M.K. Pospieszalska, A. Groisman and K. Ley "Slings enable neutrophil rolling at high shear", Nature 488, 399-403(2012) PDF

58. M. Adler and A. Groisman, "Linear conversion of pressure into concentration, rapid switching of concentration, and generation of linear ramps of concentration in a microfluidic device", Biomicrofluidics 6, 024109 (2012) PDF

57. K. Takeda, D. Shao, M. Adler, P. G. Charest, W. F. Loomis, H. Levine, A. Groisman, W.-J. Rappel, and R. A. Firtel, "Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway", Science Signaling 5, ra2 (2012) PDF


56. E. Gutierrez and A. Groisman, "Measurements of elastic moduli of silicone gel substrates with a microfluidic device", PLoS One 6, e25534 (2011) PDF

55. A. Carvalho, S. K. Olson, E. Gutierrez, K. Zhang, L. B. Noble, E. Zanin, A. Desai, A. Groisman, and K. Oegema, "Accute drug treatment in early C. elegans embryos", PLoS One 6, e24656 (2011) PDF

54.   E. Gutierrez, E. Tkachenko, A. Besser, P. Sundd, K. Ley, G. Danuser, M.H. Ginsberg, and A. Groisman, “High Refractive Index Silicone Gels for Simultaneous Total Internal Reflection Fluorescence and Traction Force Microscopy of Adherent Cells”, PLoS One 6, e23807 (2011) PDF

53.   E. Tkachenko, M. Sabouri-Ghomi, O. Pertz, C. Kim, E. Gutierrez, M. Machacek, A. Groisman, G. Danuser, M.H. Ginsberg, “Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells”, Nature Cell Biology 13, 660-667 (2011) PDF

52. P. Sundd, E. Gutierrez, B. G. Petrich, M. H. Ginsberg, A. Groisman, and K. Ley, “Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting (DqDF)”, Microcirculation 18 (2011), PDF

51. Y. Gambin, V.Vandelinder, A.C.M. Ferreon, E.A. Lemke, A. Groisman, and A.A. Deniz, “Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing”, Nature Methods 8, (2011) PDF  


50. J.V. Mitsios, N. Prévost, A. Kasirer-Friede, E. Gutierrez, A. Groisman, C. S. Abrams, Y. Wang, R. I. Litvinov, A. Zemljic-Harpf, R.S. Ross, and S.J. Shattil, “What Is Vinculin Needed for in Platelets?”, J. Thrombosis and Haemostasis 8, 2294–2304 (2010)  PDF

49. M. Skoge, M. Adler, A.Groisman, H. Levine, W. F. Loomis, and W.-J. Rappel, “Gradient sensing in defined chemotactic fields”, Integrative Biology 2, 659-668 (2010) PDF

48. P. Sundd, E. Gutierrez, M.K. Pospieszalska, H. Zhang, A. Groisman, and K. Ley, “Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophils rolling”, Nature Methods 7, 821-824,  (2010) PDF

47. D. Fuller, W. Chen, M. Adler, A. Groisman, H. Levine, W.-J. Rappel, and W. F. Loomis, “External and internal constraints on eukaryotic chemotaxis”, PNAS 107, 9656-9659 (2010) PDF

46. Y. Gambin, C. Simonnet, V. VanDelinder, A. Deniz, and A. Groisman, “Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics”, Lab on a Chip, 10, 598-609 (2010) PDF

45. M. Adler, M. Polinkovsky, E. Gutierrez, and A. Groisman, “Generation of oxygen gradients with arbitrary shapes in a microfluidic device”, Lab on a Chip, 10, 388-391 (2010) PDF


44. E. Lemke, Y. Gambin, V. VanDelinder, E.M. Brustad, H.-W. Liu, P.G. Schultz, A. Groisman, and A. Deniz, “Microfluidic Device for  Single-Molecule Experiments with Enhanced Photostability”, JACS, 131 13610–13612 (2009) PDF

43. V. Vandelinder, A.C.M. Ferreon, Y. Gambin, A.A. Deniz, and A. Groisman, “High-Resolution Temperature-Concentration Diagram of a-Synuclein Conformation Obtained from a Single Förster Resonance Energy Transfer Image in a Microfluidic Device”, Analytical Chemistry, 81, 6929–6935 (2009) PDF

42. M. Polinkovsky, E. Gutierrez, A. Levchenko, and A. Groisman, “Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures”, Lab on a Chip 9, 1073-1084 (2009) PDF

41. E. Tkachenko, E. Gutierrez, M. Ginsberg, and A. Groisman “An easy to assemble microfluidic perfusion device with a magnetic clamp”, Lab on a Chip 9, 1085-1095 (2009) PDF



40. C.J. Lim, K.H. Kain, E. Tkachenko, L.E. Goldfinger, E. Gutierrez, A. Groisman, J. Zhang, M.H. Ginsberg “Integrin-mediated protein kinase A activation at the leading edge of migrating cells”, Mol Biol Cell 19, 4930-4941 (2008) PDF

39. K. Ley, J. Mestas, M. Pospieszalska, P. Sundd, A. Groisman, and A. Zarbock, ”Intravital Microscopic Investigation of Leukocyte Interactions with the Blood Vessel Wall”, Meth. Enzymology 445, 255-279 (2008) PDF

38. A. Groisman, S. Zamek, K. Campbell, L. Pang, U. Levy, and Y. Fainman, “Optofluidic 1x4 Switch”, Optics Express 16, pp. 13499-13508   (2008) PDF

37. E. Gutierrez, B.J. Petrich, S.J. Shattil, M.H. Ginsberg, A. Groisman, and A. Kasirer-Friede, “Microfluidic Devices for Studies of Shear-Dependent Platelet Adhesion”, Lab on a Chip 8, pp. 1486–1495 (2008) PDF

36. M.I. Latz, M. Bovard, V Vandelinder, E. Segre, J. Rohr, and  A. Groisman, Bioluminescent Response of Individual Dinoflagellate Cells to Hydrodynamic Stress Measured with Millisecond Resolution in a Microfluidic Device”, Journal of Experimental Biology 211, pp. 2865-2875 (2008) PDF

35. L. E. Goldfinger, E. Tzima, R. Stockton, W. B. Kiosses, K. Kinbara, E. Tkachenko, E. Gutierrez, A. Groisman, P. Nguyen, S. Chien, and M. H. Ginsberg, “Localized α4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment”, Circulation Research 103, pp. 177-185 (2008) PDF


34. H.J. Cho, H. Jönsson, K. Campbell, P. Melke, J. W. Williams, B. Jedynak, A. M. Stevens, A. Groisman, and A. Levchenko, “Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control”, PLoS Biology 5  (11), pp. 2614-2623 (2007) PDF

33. P. Tsai, B. Migliori, K. Campbell, T.N. Kim, Z. Kam, A. Groisman, and D. Kleinfeld, “Spherical aberration correction in nonlinear microscopy and optical ablation using a transparent deformable membrane”, Applied Physics Letters 91, Art. No. 191102, (2007) PDF

32. K. Campbell, Y. Fainman, and A. Groisman, “Pneumatically actuated adaptive lenses with millisecond response time”, Applied Physics Letters 91, Art. No. 171111 (2007) PDF

31. P. Herzmark, K. Campbell, F. Wang, K. Wong, H. El-Samad, A. Groisman, and H. R. Bourne “Bound attractant at the leading vs. the trailing edge determines chemotactic prowess” PNAS 104, pp. 13349-13354 (2007) PDF

30.  S. Paliwal, P. Iglesias, K. Campbell, Z. Hilioti, A. Groisman, and A. Levchenko, "MAPK mediated bimodal gene expression and adaptive gradient sensing in yeast" Nature 446 (7131), pp. 46-51 (2007) PDF

29.  E. Gutierrez and A. Groisman, “Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfludic device”, Analytical Chemistry 79, pp. 2249-2258 (2007) PDF

28.  V. VanDelinder and A. Groisman, “Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow”, Analytical Chemistry 79, pp. 2023-2030 (2007) PDF

27.  K. Campbell and A. Groisman, “Generation of complex concentration profiles in microchannels in a logarithmically small number of steps”, Lab on a Chip 7, pp. 264-272 (2007) PDF



26.  K. Campbell, U. Levi, Y. Fainman, and A. Groisman, “Pressure-driven devices with lithographically fabricated composite epoxy-elastomer membranes”, Applied Physics Letters 89, Art. #154105 (2006) PDF

25. C. Simonnet and A. Groisman, “High-throughput and high-Resolution flow cytometry in  molded microfluidic devices”, Analytical Chemistry 78, pp. 5653-5663 (2006) PDF

24. O. Shefi, C. Simonnet, M.W. Baker, J. Glass, E. Macagno, and A. Groisman, ”Microtargeted gene silencing and ectopic expression in live  embryos using biolistic delivery with a pneumatic capillary gun”,  Journal of Neuroscience 26, pp. 6119-6123 (2006) PDF

23.  V. VanDelinder and A. Groisman, “Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device”, Analytical Chemistry 78, pp. 3765-3771 (2006) PDF

22.  U. Levi, K. Campbell, A. Groisman, S. Mookherjea and Y. Fainman, “On-chip microfluidic tuning of an optical microring resonator”, Applied Physics Letters 88, Art. No. 111107 (2006) PDF


21.  A. Groisman, C. Lobo, H. Cho, K. J. Campbell, Y. S. Dufour, A. M. Stevens and A. Levchenko, “A Microfluidic Chemostat for Experiments with bacterial and yeast cells”, Nature Methods 2, pp. 685-689 (2005) PDF

20.    L. Pang, U. Levy, K. Campbell, A. Groisman and Y. Fainman, “Set of two orthogonal adaptive cylindrical lenses in a monolith elastomer device”, Optics Express 13, pp. 9003-9013 (2005) PDF

19.   C. Simonnet and A. Groisman, “Two-dimensional hydrodynamic focusing in a simple microfluidic device”, Applied Physics Letters 87, Art. No. 114104 (2005) PDF

18.   D. Rinberg, C. Simonnet and A. Groisman, “Pneumatic capillary gun for ballistic delivery of microparticles”, Applied Physics Letters 87, Art. No. 014103 (2005) PDF

17.    T. N. Kim, K. Campbell, A. Groisman, D. Kleinfeld and C. B. Schaffer, “Femtosecond laser-drilled capillary integrated into a microfluidic device”, Applied Physics Letters 86, Art. No. 201106  (2005)  PDF

16.   C. Simonnet and A. Groisman, “Chaotic Mixing in a Steady Flow in a Microchannel”, Physical Review Letters  94, Art. No. 134501 (2005) PDF


15.   K. Campbell, A. Groisman, U. Levy, L. Pang, S. Mookherjea, D. Psaltis, and Y. Fainman, “A microfluidic 2×2 optical switch”, Applied Physics Letters 84, pp. 6119-6121 (2004) PDF

14.  T. Burghelea, E. Segre, I. Bar-Yosef, A. Groisman and V. Steinberg, “Chaotic flow and efficient mixing in microchannel with a polymer solution”, Physical Review E 69: Art. No. 066305 (2004) PDF

13  A. Groisman and V. Steinberg, “Elastic turbulence in curvilinear flows of polymer solutions”, New Journal of Physics, Art. No. 29 (2004) PDF

12. A. Groisman, and S. R. Quake, “A microfluidic rectifier: Anisotropic flow resistance at low Reynolds numbers”, Physical Review Letters,  Art. No. 094501 (2004) PDF

1994 - 2003

11. A. Groisman, M. Enzelberger and S.R. Quake, “Microfluidic memory and control devices”, Science 300, pp. 955-958 (2003) PDF

10. A. Groisman and V. Steinberg, “Efficient mixing of liquids at low Reynolds numbers using polymer additives”, Nature 410, pp. 905-908 (2001). PDF

9.   A. Groisman and V. Steinberg, “Stretching of polymers in a random three-dimensional flow”, Physical Review Letters 86, pp.934-937 (2001) PDF

8.   A. Groisman and V. Steinberg, “Elastic turbulence in a polymer solution flow”, Nature 405, pp. 53-55 (2000) PDF

7.   A. Groisman and V. Steinberg, “Mechanism of elastic instability in Couette flow of polymer solutions: experiment”, Physics of Fluids, 10, pp.2451-2463 (1998) PDF

6.   A. Groisman and V. Steinberg, “Elastic versus inertial instability in a polymer solution flow”, Europhysics Letters 43 (2), pp.165-170 (1998) PDF

5.   V. Steinberg and A. Groisman, “Elastic vs. inertial instability in Couette-Taylor flow of a polymer solution: review”, Philosophical Magazine B, 78 (2), pp.253-263 (1998) PDF

4.   A. Groisman and V. Steinberg, “Solitary vortex pairs in viscoelastic Couette flow”, Physical Review Letters 78, pp. 1460-63 (1997) PDF

3.   A. Groisman and V. Steinberg, “Couette-Taylor flow in a dilute polymer solution”, Physical Review Letters 77, pp.1480-83 (1996) PDF

2.   T. Mahr, A. Groisman and I. Rehberg, “Non-monotonic dispersion of surface waves in magnetic fluids”, Journal of Magnetism and Magnetic Materials 159, pp. L45-L50 (1996) PDF

1.   A. Groisman and E. Kaplan, “An experimental study of cracking induced by desiccation”, Europhysics Letters 25, pp.415-420 (1994) PDF