Publications by the Groisman lab.



51. Y. Gambin, V.Vandelinder, A.C.M. Ferreon, E.A. Lemke, A. Groisman, and A.A. Deniz, “Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing”, Nature Methods 8, (2011) PDF



50. J.V. Mitsios, N. Prévost, A. Kasirer-Friede, E. Gutierrez, A. Groisman, C. S. Abrams, Y. Wang, R. I. Litvinov, A. Zemljic-Harpf, R.S. Ross, and S.J. Shattil, “What Is Vinculin Needed for in Platelets?”, J. Thrombosis and Haemostasis 8, 2294–2304 (2010)  PDF

49. M. Skoge, M. Adler, A.Groisman, H. Levine, W. F. Loomis, and W.-J. Rappel, “Gradient sensing in defined chemotactic fields”, Integrative Biology 2, 659-668 (2010) PDF

48. P. Sundd, E. Gutierrez, M.K. Pospieszalska, H. Zhang, A. Groisman, and K. Ley, “Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophils rolling”, Nature Methods 7, 821-824,  (2010) PDF

47. D. Fuller, W. Chen, M. Adler, A. Groisman, H. Levine, W.-J. Rappel, and W. F. Loomis, “External and internal constraints on eukaryotic chemotaxis”, PNAS 107, 9656-9659 (2010) PDF

46. Y. Gambin, C. Simonnet, V. VanDelinder, A. Deniz, and A. Groisman, “Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics”, Lab on a Chip, 10, 598-609 (2010) PDF

45. M. Adler, M. Polinkovsky, E. Gutierrez, and A. Groisman, “Generation of oxygen gradients with arbitrary

shapes in a microfluidic device”, Lab on a Chip, 10, 388-391 (2010) PDF



44. E. Lemke, Y. Gambin, V. VanDelinder, E.M. Brustad, H.-W. Liu, P.G. Schultz, A. Groisman, and A. Deniz, “Microfluidic Device for  Single-Molecule Experiments with Enhanced Photostability”, JACS, 131 13610–13612 (2009) PDF

43. V. Vandelinder, A.C.M. Ferreon, Y. Gambin, A.A. Deniz, and A. Groisman, “High-Resolution Temperature-Concentration Diagram of a-Synuclein Conformation Obtained from a Single Förster Resonance Energy Transfer Image in a Microfluidic Device”, Analytical Chemistry, 81, 6929–6935 (2009) PDF

42. M. Polinkovsky, E. Gutierrez, A. Levchenko, and A. Groisman, “Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures”, Lab on a Chip 9, 1073-1084 (2009) PDF

41. E. Tkachenko, E. Gutierrez, M. Ginsberg, and A. Groisman “An easy to assemble microfluidic perfusion device with a magnetic clamp”, Lab on a Chip 9, 1085-1095 (2009) PDF


40. C.J. Lim, K.H. Kain, E. Tkachenko, L.E. Goldfinger, E. Gutierrez, A. Groisman, J. Zhang, M.H. Ginsberg “Integrin-mediated protein kinase A activation at the leading edge of migrating cells”, Mol Biol Cell 19, 4930-4941 (2008) PDF

39. K. Ley, J. Mestas, M. Pospieszalska, P. Sundd, A. Groisman, and A. Zarbock,

 ”Intravital Microscopic Investigation of Leukocyte Interactions with the Blood

Vessel Wall”, Meth. Enzymology 445, 255-279 (2008) PDF

38. A. Groisman, S. Zamek, K. Campbell, L. Pang, U. Levy, and Y. Fainman, “Optofluidic 1x4 Switch”, Optics Express 16, pp. 13499-13508   (2008) PDF

37. E. Gutierrez, B.J. Petrich, S.J. Shattil, M.H. Ginsberg, A. Groisman, and

A. Kasirer-Friede, “Microfluidic Devices for Studies of Shear-Dependent

Platelet Adhesion”, Lab on a Chip 8, pp. 1486–1495 (2008) PDF

36. M.I. Latz, M. Bovard, V Vandelinder, E. Segre, J. Rohr, and  A. Groisman, Bioluminescent Response of Individual Dinoflagellate Cells to Hydrodynamic Stress Measured with Millisecond Resolution in a Microfluidic Device”, Journal of Experimental Biology 211, pp. 2865-2875 (2008) PDF

35. L. E. Goldfinger, E. Tzima, R. Stockton, W. B. Kiosses, K. Kinbara, E. Tkachenko, E. Gutierrez, A. Groisman, P. Nguyen, S. Chien, and M. H. Ginsberg, “Localized α4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment”, Circulation Research 103, pp. 177-185 (2008) PDF


34. H.J. Cho, H. Jönsson, K. Campbell, P. Melke, J. W. Williams, B. Jedynak, A. M. Stevens, A. Groisman, and A. Levchenko, “Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control”, PLoS Biology 5  (11), pp. 2614-2623 (2007) PDF

33. P. Tsai, B. Migliori, K. Campbell, T.N. Kim, Z. Kam, A. Groisman, and D. Kleinfeld, “Spherical aberration correction in nonlinear microscopy and optical ablation using a transparent deformable membrane”, Applied Physics Letters 91, Art. No. 191102, (2007) PDF

32. K. Campbell, Y. Fainman, and A. Groisman, “Pneumatically actuated adaptive lenses with millisecond response time”, Applied Physics Letters 91, Art. No. 171111 (2007) PDF

31. P. Herzmark, K. Campbell, F. Wang, K. Wong, H. El-Samad, A. Groisman, and H. R. Bourne “Bound attractant at the leading vs. the trailing edge determines chemotactic prowess” PNAS 104, pp. 13349-13354 (2007) PDF

30.  S. Paliwal, P. Iglesias, K. Campbell, Z. Hilioti, A. Groisman, and A. Levchenko,

"MAPK mediated bimodal gene expression and adaptive gradient sensing

in yeast" Nature 446 (7131), pp. 46-51 (2007) PDF

29.  E. Gutierrez and A. Groisman, “Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfludic device”, Analytical Chemistry 79, pp. 2249-2258 (2007) PDF

28.  V. VanDelinder and A. Groisman, “Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow”, Analytical Chemistry 79, pp. 2023-2030 (2007) PDF

27.  K. Campbell and A. Groisman, “Generation of complex concentration profiles in microchannels in a logarithmically small number of steps”, Lab on a Chip 7, pp. 264-272 (2007) PDF


26.  K. Campbell, U. Levi, Y. Fainman, and A. Groisman, “Pressure-driven devices with lithographically fabricated composite epoxy-elastomer membranes”, Applied Physics Letters 89, Art. #154105 (2006) PDF

25. C. Simonnet and A. Groisman, “High-throughput and high-Resolution flow cytometry in

 molded microfluidic devices”, Analytical Chemistry 78, pp. 5653-5663 (2006) PDF

24. O. Shefi, C. Simonnet, M.W. Baker, J. Glass, E. Macagno, and A. Groisman, ”Microtargeted gene silencing and ectopic expression in live  embryos using biolistic delivery with a pneumatic capillary gun”,  Journal of Neuroscience 26, pp. 6119-6123 (2006) PDF

23.  V. VanDelinder and A. Groisman, “Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device”, Analytical Chemistry 78, pp. 3765-3771 (2006) PDF

22.  U. Levi, K. Campbell, A. Groisman, S. Mookherjea and Y. Fainman, “On-chip microfluidic tuning of an optical microring resonator”, Applied Physics Letters 88, Art. No. 111107 (2006) PDF


21.  A. Groisman, C. Lobo, H. Cho, K. J. Campbell, Y. S. Dufour, A. M. Stevens and A. Levchenko, 
“A Microfluidic Chemostat for Experiments with bacterial and yeast cells”, Nature Methods 2, pp.
 685-689 (2005) PDF 

20.    L. Pang, U. Levy, K. Campbell, A. Groisman and Y. Fainman, “Set of two orthogonal adaptive cylindrical lenses in a monolith elastomer device”, Optics Express 13, pp. 9003-9013 (2005) PDF

19.   C. Simonnet and A. Groisman, “Two-dimensional hydrodynamic focusing in a simple microfluidic device”, Applied Physics Letters 87, Art. No. 114104 (2005) PDF

18.   D. Rinberg, C. Simonnet and A. Groisman, “Pneumatic capillary gun for ballistic delivery of microparticles”, Applied Physics Letters 87, Art. No. 014103 (2005) PDF

17.    T. N. Kim, K. Campbell, A. Groisman, D. Kleinfeld and C. B. Schaffer, “Femtosecond laser-drilled capillary integrated into a microfluidic device”, Applied Physics Letters 86, Art. No. 201106  (2005)  PDF

16.   C. Simonnet and A. Groisman, “Chaotic Mixing in a Steady Flow in a Microchannel”, Physical Review Letters  94, Art. No. 134501 (2005) PDF


15.   K. Campbell, A. Groisman, U. Levy, L. Pang, S. Mookherjea, D. Psaltis, and Y. Fainman, “A microfluidic 2×2 optical switch”, Applied Physics Letters 84, pp. 6119-6121 (2004) PDF

14.  T. Burghelea, E. Segre, I. Bar-Yosef, A. Groisman and V. Steinberg, “Chaotic flow and efficient mixing

in microchannel with a polymer solution”, Physical Review E 69: Art. No. 066305 (2004) PDF

13  A. Groisman and V. Steinberg, “Elastic turbulence in curvilinear flows of polymer solutions”, New Journal of Physics, Art. No. 29 (2004) PDF

12. A. Groisman, and S. R. Quake, “A microfluidic rectifier: Anisotropic flow resistance at low Reynolds numbers”, Physical Review Letters,  Art. No. 094501 (2004) PDF

1994 - 2003

11. A. Groisman, M. Enzelberger and S.R. Quake, “Microfluidic memory and control devices”, Science 300, pp. 955-958 (2003) PDF

10. A. Groisman and V. Steinberg, “Efficient mixing of liquids at low Reynolds numbers using polymer additives”, Nature 410, pp. 905-908 (2001). PDF

9.   A. Groisman and V. Steinberg, “Stretching of polymers in a random three-dimensional flow”, Physical Review Letters 86, pp.934-937 (2001) PDF

8.   A. Groisman and V. Steinberg, “Elastic turbulence in a polymer solution flow”, Nature 405, pp. 53-55 (2000) PDF

7.   A. Groisman and V. Steinberg, “Mechanism of elastic instability in Couette flow of polymer solutions: experiment”, Physics of Fluids, 10, pp.2451-2463 (1998) PDF

6.   A. Groisman and V. Steinberg, “Elastic versus inertial instability in a polymer solution flow”, Europhysics Letters 43 (2), pp.165-170 (1998) PDF

5.   V. Steinberg and A. Groisman, “Elastic vs. inertial instability in Couette-Taylor flow of a polymer solution: review”, Philosophical Magazine B, 78 (2), pp.253-263 (1998) PDF

4.   A. Groisman and V. Steinberg, “Solitary vortex pairs in viscoelastic Couette flow”, Physical Review Letters 78, pp. 1460-63 (1997) PDF

3.   A. Groisman and V. Steinberg, “Couette-Taylor flow in a dilute polymer solution”, Physical Review Letters 77, pp.1480-83 (1996) PDF

2.   T. Mahr, A. Groisman and I. Rehberg, “Non-monotonic dispersion of surface waves in magnetic fluids”, Journal of Magnetism and Magnetic Materials 159, pp. L45-L50 (1996) PDF

1.   A. Groisman and E. Kaplan, “An experimental study of cracking induced by desiccation”, Europhysics Letters 25, pp.415-420 (1994) PDF



4. “Microfluidic system and method for using same”, with E. Gutierrez, E. Tkachenko, and M. Ginsberg, US utility application filed in 2010

3. Microfluidic device and method for high-throughput cellular gradient and dose response studies”, with S. Paliwal and A. Levchenko, US utility application No. 20100035292, published 02/11/2010 PDF

2. “Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue”, with D. Rinberg and C. Simonnet, US patent application No. 20080206870, published 08/28/2008 PDF

1. “Device and method for mixing substances”, with V. Steinberg, US patent #6,632,014 (2003) PDF


Media reports and feature articles highlighting our work.

Research journals and magazines.

“Enhanced photostability of fluorophors”, by Petra Dittrich, Lab on a Chip 9, 3176 (2009) PDF

 “An adjustable corrective lens for two-photon microscopy”, by Hank Hogan, Biophotonics International, Jan. 2008, p. 18-19 PDF

“Self-organization in bacterial colonies”, research highlight by Petra Dittrich, Lab on a Chip 8, p. 197 (2008) PDF

 “Biofilms”, Research highlight in brief, Nature Reviews Microbiology, Dec. 2007 PDF

“Crowd control”, Research highlight, Nature 450, 322 (2007) PDF

 “Flow cytometry moves forward”, by Hank Hogan, Biophotonics International, Nov. 2006, p. 38-40.

“Szilard's dream”, by Nathalie Q Balaban, Nature Methods 2, pp. 648-649 (2005) PDF

“Microfluids change direction”, by Nicolas Garnier, Physics World, June 2004, p.22

 “Microfluidic Memory”, by Andrew de Mello, Lab on a Chip, 3, p. 35N, 2003 PDF

“Nichlineare rheologie. - Flüssige Mikroschalter” (In German. “Non-linear rheology. – Liquid micro-switch”), by Volker Drach, Physik in Unserer Zeit, 34 (5), p.200 (2003)  PDF

“Controlling the flow”, by Melanie Brazil, Nature Reviews Drug Discovery 2, p. 510 (2003) PDF

 “Turbulence without inertia”, by Ronald G. Larson, Nature 405, pp. 27-28 (2000) PDF


On-line media and newspapers.

Understanding Biofilms”, by Amy Proal, Bacteriality: exploring chronic decease, 2008

Microfluidic device may reveal ways to fight antibiotic-resistant biofilms”, Medical News Today, November 14, 2007

Together we stand: bacteria organize to survive hostile zones”,, November 13, 2007

 “Efficient crowd control in bacterial colonies”,  ScienceDaily, Oct. 31, 2007

 “Slime city reveals how bacteria cooperate”, MSNBC Technology and Science, November 20, 2007

Bacterial crowd control”, MicorbiologyBytes, December 21, 2007

Welcome to the Micro-Hotel California”, Dec 2, 2007

 Self-organisation among bacteria”, by Thomas Hesselberg, Life of Science, October 31, 2007

Microfluidic chip helps solve cellular mating puzzle”, EurekaAlert, February 2007    

 Cross-flow microdevice enables plasma separation”,, June 19, 2006

Triangles form one-way channels”, Technology Research News, March 24, 2004,Femtosecond Laser Brings 3-D to Microfluidics”, Photonics Spectra, August 2005

 “Liquid Diode designed”, SETSquared, April 5, 2004

Microfluids change direction”, Physics Web, June 2004

Panschen im Kleinen: Fliesskontrolle und Datenspeicher mit flussigen Polymeren” (In German. “Splashes in small: flow control and data storage with liquid polymers”), Wissenschaft-online, May 9, 2003

’Simple, cheap technology’ hold huge promise”, by United Press International, SmallTimes news report, May 2003

“Liquid memory devices, drug dispensers”, The Washington Times, May 8, 2003

  “Diabetes Therapies and Liquid Memory May Develop from Micro Fluid Research, Science Researchers Say”,  American Association for the Advancement of Science news report, 8 May 2003

 “Microfluidics go nonlinear”, Technology Research News, May 29, 2003  “Turbulence turns elastic”, Physics Web, May 5, 2000